¹See: Maher YA, Rajeh MT, Hamooda FA et al. Evaluation of the Clinical Impact and In Vitro Antibacterial Activities of Two Bioactive Restoratives against S. mutans ATCC 25175 in Class II Carious Restorations, Nigerian Journal of Clinical Practice, 2023;26(4):404-411; and Mah J, Merritt J, Ferracane J. Adhesion of S. mutans biofilms on potentially antimicrobial dental composites. J Dent Res. 2017;96: 2560. 

²The remineralization process is a natural repair mechanism to restore the minerals again—in ionic forms—to the hydroxyapatite (HAP) crystal lattice. Source: Arifa MK, Ephraim R, Rajamani T. Recent advances in dental hard tissue remineralization: a review of literature. Intl J Clin Ped Dent. 2019:12;2:139. 

³Activa Bioactive physically seals the margin of the material and tooth interface through mineral apatite formation, subsequently protecting against microleakage, the leading cause of secondary caries and recurrent decay. Scanning electron micrographs of the Activa Bioactive Restorative groups showed a ‘‘thicker acid-base resistant hybrid-like layer with a distinct crystallization pattern.’’ (Raghip AG, Comisi JC, Hamama HH, Mahmoud SH. In vitro elemental and micromorphological analysis of the resin-dentin interface of bioactive and bulk-fill composites. Am J Dent. 2023;36{1}:3-7.) 

⁴“One-step” describes placement after preparation, etching, and bonding steps. Refer to Activa Bioactive Bulk Flow instructions for use (IFU) for full complete instructions.

⁵Dual-cure mode 

⁶Activa Bioactive Bulk Flow shrinkage stress rate testing within same statistical grouping as SDR Flow. Source: Independent university testing; publication pending (2025): American Association for Dental, Oral, and Craniofacial Research.